Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated

Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. MUC-1 can act both as an adhesion and an anti-adhesion protein. This protein may provide a protective layer on epithelial cells against bacterial and enzyme attack. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras/MAPK pathway. MUC-1 promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.

规格	价格/CNY		货期	数量
20 μg	￥ 2,260	5日内发货
100 μg	￥ 6,130	5日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 2,260

5日内发货

100 μg

￥ 6,130

5日内发货

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-hFc-Avi
蛋白编号	P15941-11
别名	Polymorphic epithelial mucin, KL-6, Cancer antigen 15-3, PEMT, PUM, H23AG, Krebs von den Lungen-6, PEM, Carcinoma-associated mucin, Mucin-1, Episialin, Breast carcinoma-associated antigen DF3, CA 15-3, MUC-1, Peanut-reactive urinary mucin, Tumor-associate
氨基酸序列	Pro24-Gly167
蛋白构建	Pro24-Gly167
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	55-75 KDa, reducing conditions

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. MUC-1 can act both as an adhesion and an anti-adhesion protein. This protein may provide a protective layer on epithelial cells against bacterial and enzyme attack. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras/MAPK pathway. MUC-1 promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.

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Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated

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