IL-4R alpha Protein, Mouse, Recombinant (hFc)

Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

规格	价格/CNY		数量
10 μg	￥ 700	现货
50 μg	￥ 1,970	5日内发货
500 μg	￥ 9,960	5日内发货
1 mg	￥ 14,200	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 700

现货

50 μg

￥ 1,970

5日内发货

500 μg

￥ 9,960

5日内发货

1 mg

￥ 14,200

5日内发货

生物活性

1. Loaded Mouse IL-4-His on HIS1K Biosensor, can bind Mouse IL-4RA-Fc with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Mouse IL-4RA-Fc at 2μg/ml (100 μl/well)can bind Mouse IL-4-His . The ED50 of Mouse IL-4-Hisis 4.32 ng/ml. (Regularly tested)

TargetMol Bioactive

产品描述

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P16382
别名	Soluble IL-4R-alpha, Interleukin-4 receptor subunit alpha, Soluble IL-4R-α, CD124, IL-4R-α, IL-4R-alpha, Interleukin-4 receptor subunit α, IL4-BP
氨基酸序列	Ile26-Arg233
蛋白构建	Ile26-Arg233
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	65-80 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

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复溶计算器

重组蛋白稀释计算器

比活力计算器

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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IL-4R alpha Protein, Mouse, Recombinant (hFc)

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