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HER2/ERBB2 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00745

别名: NEU, CD340, HER-2/neu, HERV7Q, TKR1, erb-b2 receptor tyrosine kinase 2, MLN19, MLN 19, ERVWE1, ENV, HERVW, HERV-7q, HER-2, HERVWENV, EGFR2, NGL, HER2, ENVW, HERV-W-ENV

HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.

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HER2/ERBB2 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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参考文献

生物活性	1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag) at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL. 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 µg/mL Anti-ErbB2/Her2 Monoclonal Antibody.
产品描述	HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P04626-1
别名	NEU, CD340, HER-2/neu, HERV7Q, TKR1, erb-b2 receptor tyrosine kinase 2, MLN19, MLN 19, ERVWE1, ENV, HERVW, HERV-7q, HER-2, HERVWENV, EGFR2, NGL, HER2, ENVW, HERV-W-ENV
蛋白构建	The extracellular domain (Met 1-Thr 652) of Human ErbB2 (NP_004439.2) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	96.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Krawczyk N,et al.(2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.

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Keywords

HER2/ERBB2 Protein, Human, Recombinant (hFc) NEU CD340 HER-2/neu HERV7Q TKR1 CD-340 TKR 1 erb-b2 receptor tyrosine kinase 2 MLN19 MLN-19 MLN 19 ERVWE1 ENV CD 340 HERVW HERV-7q TKR-1 HER-2 HERVWENV HER 2 EGFR2 ERVWE 1 NGL HER2 ENVW ERVWE-1 HERV-W-ENV recombinant recombinant-proteins proteins protein

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