BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 1,250 | 5日内发货 | ||
100 μg | ¥ 4,920 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | N-rFc |
蛋白编号 | P21275 |
别名 | bone morphogenetic protein 4, Bmp-4, Bmp2b-1, Bmp2b, Bmp2b1 |
蛋白构建 | The Mouse BMP4 (NP_031580.2) (Ser293-Arg408) was expressed with the Fc region of rabbit IgG at the N-terminus.. |
蛋白纯度 | > 92 % as determined by SDS-PAGE. |
分子量 | 40.6 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling. |
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BMP-4 Protein, Mouse, Recombinant (rFc) bone morphogenetic protein 4 Bmp-4 Bmp2b-1 Bmp2b Bmp2b1 recombinant recombinant-proteins proteins protein