Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypophyllanthin 是珠子草中的一种木脂素,能直接抑制 P-gp 的活性,具有很强的抗炎活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 987 | 现货 | ||
5 mg | ¥ 2,620 | 现货 | ||
10 mg | ¥ 3,830 | 现货 | ||
25 mg | ¥ 5,970 | 现货 | ||
50 mg | ¥ 8,220 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,710 | 现货 |
产品描述 | Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. |
体外活性 | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1] |
别名 | 叶下珠次素, (7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂 |
分子量 | 430.49 |
分子式 | C24H30O7 |
CAS No. | 33676-00-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (232.29 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3229 mL | 11.6147 mL | 23.2293 mL | 58.0734 mL |
5 mM | 0.4646 mL | 2.3229 mL | 4.6459 mL | 11.6147 mL | |
10 mM | 0.2323 mL | 1.1615 mL | 2.3229 mL | 5.8073 mL | |
20 mM | 0.1161 mL | 0.5807 mL | 1.1615 mL | 2.9037 mL | |
50 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 1.1615 mL | |
100 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5807 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hypophyllanthin 33676-00-5 Membrane transporter/Ion channel Metabolism Neuroscience P-gp Calcium Channel Potassium Channel Inhibitor CD243 Pgp 叶下珠次素 inhibit ABCB1 (7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂 P-glycoprotein Cluster of differentiation 243 Multidrug resistance protein 1 MDR1 inhibitor