Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gypsogenin (639-14-5) 是一种天然存在的生化物质,具有明显的抗血管生成活性和对 H460 的细胞毒性,拥有抗 ABL1 激酶和抗慢性骨髓性白血病作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 981 | 现货 | ||
5 mg | ¥ 2,490 | 现货 | ||
10 mg | ¥ 3,690 | 现货 | ||
25 mg | ¥ 5,980 | 现货 | ||
50 mg | ¥ 8,270 | 现货 | ||
100 mg | ¥ 10,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,490 | 现货 |
产品描述 | Gypsogenin (639-14-5) is a naturally occurring biochemical that shows anti-ABL1 kinase and anti-chronic Myelogenous Leukemia activities. |
体外活性 | Gypsogenin (1) was obtained by acidic hydrolysis from its saponin.?While the parent compound 1 acted as a selective inhibitor for butyrylcholinesterase (from equus) possessing a moderate mixed-type inhibition of the enzyme, Ki values as low as 2.67 0.59 μM were determined for (3β,4α) 3-O-acetyl-olean-12-ene-23,28-dinitrile (11) and acetylcholinesterase (AChE, from electric eel).?Thus, 11 possesses one-fifth of the inhibitory activity of the 'gold standard' galantamine hydrobromide;?this compound is one of the first pentacyclic triterpenoids described as a potent AChE-selective inhibitor |
别名 | 丝石竹皂苷元 |
分子量 | 470.68 |
分子式 | C30H46O4 |
CAS No. | 639-14-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/ml (58.42 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL | 53.1146 mL |
5 mM | 0.4249 mL | 2.1246 mL | 4.2492 mL | 10.6229 mL | |
10 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL | 5.3115 mL | |
20 mM | 0.1062 mL | 0.5311 mL | 1.0623 mL | 2.6557 mL | |
50 mM | 0.0425 mL | 0.2125 mL | 0.4249 mL | 1.0623 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gypsogenin 639-14-5 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl 丝石竹皂苷元 inhibit Inhibitor inhibitor