Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirofiban (L700462) 是一种非肽类选择性 GPIIb/IIIa 拮抗剂,IC50 为 9 nM,可抑制血小板聚集。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 119 | 现货 | ||
5 mg | ¥ 233 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 752 | 现货 | ||
50 mg | ¥ 1,180 | 现货 | ||
100 mg | ¥ 1,890 | 现货 | ||
500 mg | ¥ 4,580 | 现货 |
产品描述 | Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. |
靶点活性 | GPIIb/IIIa:9 nM |
体外活性 | Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μMol/L. [3] |
体内活性 | Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [4] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [5][6] |
别名 | L700462, Aggrastat, 替罗非班, MK383 |
分子量 | 440.6 |
分子式 | C22H36N2O5S |
CAS No. | 144494-65-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tirofiban 144494-65-5 Cytoskeletal Signaling Integrin VEGF AMI MK-383 Inhibitor inhibit L700462 ACSs antithrombotic L 700462 Aggrastat HAEC MK 383 替罗非班 HUVEC L-700462 MK383 inhibitor