Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tempol (Tanol) 是一种超氧化物歧化酶类似物,可有效中和活性氧,具有抗炎、神经保护和镇痛作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 148 | 现货 | ||
200 mg | ¥ 372 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 413 | 现货 |
产品描述 | Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects. |
体外活性 | Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
体内活性 | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
细胞实验 | The antiproliferative effect of Tempol is assessed by the MTT assay after 96 h exposure of the cells to the drug. Briefly, 100,000 cells/mL are seeded onto 96-well plates and allowed to grow for 24 h before treatment with different concentrations of Tempol (0.05–1.6 mM).(Only for Reference) |
别名 | TMPN, Tanol, 4-Hydroxy-TEMPO, 阻聚剂701 |
分子量 | 172.25 |
分子式 | C9H18NO2 |
CAS No. | 2226-96-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (580.59 mM ), Sonification is recommended
Ethanol: 17.2 mg/mL (100 mM)
DMSO: 17.2 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / Ethanol / DMSO | 1 mM | 5.8055 mL | 29.0276 mL | 58.0552 mL | 145.1379 mL |
5 mM | 1.1611 mL | 5.8055 mL | 11.611 mL | 29.0276 mL | |
10 mM | 0.5806 mL | 2.9028 mL | 5.8055 mL | 14.5138 mL | |
20 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL | 7.2569 mL | |
50 mM | 0.1161 mL | 0.5806 mL | 1.1611 mL | 2.9028 mL | |
100 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4514 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tempol 2226-96-2 Autophagy Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species ROS inhibit TMPN Inhibitor Tanol 4-Hydroxy-TEMPO 阻聚剂701 inhibitor