Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 199 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 318 | 现货 |
产品描述 | Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. |
激酶实验 | Protein Kinase profiling assay: Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28. |
分子量 | 337.56 |
分子式 | C20H35NOS |
CAS No. | 54767-75-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (148.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9624 mL | 14.8122 mL | 29.6244 mL | 74.0609 mL |
5 mM | 0.5925 mL | 2.9624 mL | 5.9249 mL | 14.8122 mL | |
10 mM | 0.2962 mL | 1.4812 mL | 2.9624 mL | 7.4061 mL | |
20 mM | 0.1481 mL | 0.7406 mL | 1.4812 mL | 3.703 mL | |
50 mM | 0.0592 mL | 0.2962 mL | 0.5925 mL | 1.4812 mL | |
100 mM | 0.0296 mL | 0.1481 mL | 0.2962 mL | 0.7406 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Suloctidil 54767-75-8 Membrane transporter/Ion channel Others ATPase Platelet aggregation Inhibitor Na+/K+ ATPase inhibit Sodium potassium pump inhibitor