Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 453 | 现货 | ||
5 mg | ¥ 936 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 2,960 | 现货 | ||
50 mg | ¥ 4,370 | 现货 | ||
100 mg | ¥ 6,230 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,420 | 现货 |
产品描述 | Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. |
体外活性 | Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion. |
别名 | Solamargin, δ-Solanigrine, 澳洲茄边碱 |
分子量 | 868.06 |
分子式 | C45H73NO15 |
CAS No. | 20311-51-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91 mg/mL(104.8 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.152 mL | 5.76 mL | 11.5199 mL | 28.7999 mL |
5 mM | 0.2304 mL | 1.152 mL | 2.304 mL | 5.76 mL | |
10 mM | 0.1152 mL | 0.576 mL | 1.152 mL | 2.88 mL | |
20 mM | 0.0576 mL | 0.288 mL | 0.576 mL | 1.44 mL | |
50 mM | 0.023 mL | 0.1152 mL | 0.2304 mL | 0.576 mL | |
100 mM | 0.0115 mL | 0.0576 mL | 0.1152 mL | 0.288 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Solamargine 20311-51-7 Apoptosis JAK/STAT signaling MAPK Membrane transporter/Ion channel Neuroscience Stem Cells p38 MAPK P-gp STAT Inhibitor cytotoxicity cells Cluster of differentiation 243 MDR1 Pgp Solamargin P-glycoprotein ABCB1 inhibit cancer gastric delta-Solanigrine δ-Solanigrine Multidrug resistance protein 1 CD243 HepG2 澳洲茄边碱 inhibitor