Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Salicylanilide (2-Hydroxybenzanilide) 有广泛的生物学特性,如抗病毒、菌和抗真菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 289 | 现货 | ||
100 mg | ¥ 413 | 现货 | ||
200 mg | ¥ 583 | 现货 | ||
500 mg | ¥ 963 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 385 | 现货 |
产品描述 | Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities. |
体外活性 | Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus could be potentially afflicted by salicylanilides on the level of two enzymes – NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazole derivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds.[1] Salicylanilides is potential virulence inhibitors attributable to a blockade of the type III secretion pathway. Many salicylanilide ester derivatives have been demonstrated an effective and promising treatment against pathogenic fungi and bacteria (especially against Gram-positive, tuberculous and atypical mycobacterial strains), including strains such as methicillinresistant Staphylococcus aureus and isoniazid-resistant mycobacteria which are resistant to one or more clinically used drugs.[2] |
别名 | WR10019, 2-Hydroxybenzanilide, 水杨酰苯胺 |
分子量 | 213.23 |
分子式 | C13H11NO2 |
CAS No. | 87-17-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 15 mg/mL (70.3 mM)
DMSO: 40 mg/mL (187.6 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 4.6898 mL | 23.4489 mL | 46.8977 mL | 117.2443 mL |
5 mM | 0.938 mL | 4.6898 mL | 9.3795 mL | 23.4489 mL | |
10 mM | 0.469 mL | 2.3449 mL | 4.6898 mL | 11.7244 mL | |
20 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL | 5.8622 mL | |
50 mM | 0.0938 mL | 0.469 mL | 0.938 mL | 2.3449 mL | |
DMSO | 100 mM | 0.0469 mL | 0.2345 mL | 0.469 mL | 1.1724 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Salicylanilide 87-17-2 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase WR 10019 HIV Human immunodeficiency virus HIV Integrase WR10019 inhibit Inhibitor WR-10019 2-Hydroxybenzanilide 水杨酰苯胺 inhibitor