Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Salermide 是一种 Sirt1 和 Sirt2 的抑制剂,可诱导强烈的癌症特异性细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 186 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 579 | 现货 | ||
25 mg | ¥ 1,070 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 2,970 | 现货 | ||
500 mg | ¥ 6,850 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
体外活性 | Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1]. |
体内活性 | Salermide is well tolerated by mice at concentrations up to 100?μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1]. |
细胞实验 | Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100?μm) for 24?h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.(Only for Reference) |
分子量 | 394.47 |
分子式 | C26H22N2O2 |
CAS No. | 1105698-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 39.5 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.535 mL | 12.6752 mL | 25.3505 mL | 63.3762 mL |
5 mM | 0.507 mL | 2.535 mL | 5.0701 mL | 12.6752 mL | |
10 mM | 0.2535 mL | 1.2675 mL | 2.535 mL | 6.3376 mL | |
20 mM | 0.1268 mL | 0.6338 mL | 1.2675 mL | 3.1688 mL | |
50 mM | 0.0507 mL | 0.2535 mL | 0.507 mL | 1.2675 mL | |
100 mM | 0.0254 mL | 0.1268 mL | 0.2535 mL | 0.6338 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Salermide 1105698-15-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibit inhibitor