Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂,是一种有效的亚微摩尔端粒酶抑制剂,IC50为0.33 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 162 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,280 | 现货 | ||
50 mg | ¥ 2,390 | 现货 | ||
100 mg | ¥ 3,630 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 496 | 现货 |
产品描述 | RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar. |
靶点活性 | telomerase in the TRAP assay:0.33 μM (IC50) |
体外活性 | CP 673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors. In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence. [2] |
别名 | RHPS 4 methosulfate, NSC714187 |
分子量 | 458.48 |
分子式 | C22H17F2N2·CH3O4S |
CAS No. | 390362-78-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91 mg/mL (198.48 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1811 mL | 10.9056 mL | 21.8112 mL | 54.528 mL |
5 mM | 0.4362 mL | 2.1811 mL | 4.3622 mL | 10.9056 mL | |
10 mM | 0.2181 mL | 1.0906 mL | 2.1811 mL | 5.4528 mL | |
20 mM | 0.1091 mL | 0.5453 mL | 1.0906 mL | 2.7264 mL | |
50 mM | 0.0436 mL | 0.2181 mL | 0.4362 mL | 1.0906 mL | |
100 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5453 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RHPS4 390362-78-4 Apoptosis DNA Damage/DNA Repair Telomerase HT29 RHPS-4 NSC 714187 breast cancer Inhibitor inhibit RHPS 4 methosulfate NSC-714187 M14 PC3 H460 RHPS 4 H2AX CG5 NSC714187 inhibitor