Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 185 | 现货 | ||
10 mg | ¥ 258 | 现货 | ||
25 mg | ¥ 413 | 现货 | ||
50 mg | ¥ 663 | 现货 | ||
100 mg | ¥ 1,080 | 现货 | ||
200 mg | ¥ 1,580 | 现货 | ||
500 mg | ¥ 2,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 227 | 现货 |
产品描述 | Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy. |
别名 | Rythmol, 普罗帕酮, Propafenonum |
分子量 | 341.44 |
分子式 | C21H27NO3 |
CAS No. | 54063-53-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (73.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9288 mL | 14.6439 mL | 29.2877 mL | 73.2193 mL |
5 mM | 0.5858 mL | 2.9288 mL | 5.8575 mL | 14.6439 mL | |
10 mM | 0.2929 mL | 1.4644 mL | 2.9288 mL | 7.3219 mL | |
20 mM | 0.1464 mL | 0.7322 mL | 1.4644 mL | 3.661 mL | |
50 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL | 1.4644 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Propafenone 54063-53-5 Immunology/Inflammation Membrane transporter/Ion channel Potassium Channel MRP Sodium Channel Isus KcsA Rythmol Drug repositioning mitochondria dysfunction SA-79 apoptosis esophageal Ito SA79 普罗帕酮 Propafenonum Adrenergic Receptor inhibit ESCC antiarrhythmic agent mitochondrial dysfunction Na+ channels Inhibitor SA 79 Beta Receptor sodium-channel blocker Na channels inhibitor