store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PU-H71是一种选择性的HSP90抑制剂,IC50= 51 nM。
产品描述 | PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM. |
靶点活性 | HSP90:51 nM |
体外活性 | PU-H71(1 μ M) potently inhibits the growth of triple negative breast cancer (TNBC) cell lines MDA-MB-468, MDA-MB-231, and HCC-1806, with IC50 values of 65, 140, and 87 nM, respectively. PU-H71(1 μ M) kills 80%, 65%, and 80% of MDA-MB-468, MDA-MB-231, and HCC-1806 cells, respectively[1]. |
体内活性 | MDA-MB-231 model treated with PU-H71 at a dose of 75 mg/kg was 100% fully effective. After 37 days of treatment, tumor was replaced by scar tissue, accompanied by a reduction in many proliferative and anti apoptotic molecules, such as EGFR, HER3, Raf-1, Akt, and p-Akt, which decreased by 80%, 95%, 99%, 80%, and 65%, respectively. PU-H71 (75 mg/kg, three times a week) inhibits tumor growth by 96%, reduces tumor cell proliferation by 60%, decreases activated Akt associated with survival and high invasive potential by 85%, and increases apoptosis by 6-fold[1]. |
分子量 | 512.37 |
分子式 | C18H21IN6O2S |
CAS No. | 873436-91-0 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.1 mg/mL (89.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9517 mL | 9.7586 mL | 19.5171 mL | 48.7929 mL |
5 mM | 0.3903 mL | 1.9517 mL | 3.9034 mL | 9.7586 mL | |
10 mM | 0.1952 mL | 0.9759 mL | 1.9517 mL | 4.8793 mL | |
20 mM | 0.0976 mL | 0.4879 mL | 0.9759 mL | 2.4396 mL | |
50 mM | 0.039 mL | 0.1952 mL | 0.3903 mL | 0.9759 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PU-H71 873436-91-0 Cytoskeletal Signaling Metabolism HSP PUH71 PU H71 Inhibitor inhibitor inhibit