Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-04418948 是一种可口服的,选择性的前列腺素EP2受体拮抗剂,IC50为16 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 278 | 现货 | ||
5 mg | ¥ 539 | 现货 | ||
10 mg | ¥ 765 | 现货 | ||
25 mg | ¥ 1,653 | 现货 | ||
50 mg | ¥ 2,862 | 现货 | ||
100 mg | ¥ 3,170 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 574 | 现货 |
产品描述 | PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). |
靶点活性 | EP2 receptor:16 nM |
体内活性 | Eslicarbazepine acetate(ESL) has Anticonvulsant effects on the development of latrunculin A-induced seizures and paroxysmal EEG activity. ESL may also exhibit disease-modifying effects beyond suppressing just seizure activity, possibly by altering the development of a hyperexcitable network, as evidenced by the suppressed changes in glycine, taurine, glutamate and aspartate concentrations associated with an antiepileptogenic effect[1]. |
别名 | PF 04418948, PF04418948 |
分子量 | 409.41 |
分子式 | C23H20FNO5 |
CAS No. | 1078166-57-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40.9 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4425 mL | 12.2127 mL | 24.4254 mL | 61.0635 mL |
5 mM | 0.4885 mL | 2.4425 mL | 4.8851 mL | 12.2127 mL | |
10 mM | 0.2443 mL | 1.2213 mL | 2.4425 mL | 6.1063 mL | |
20 mM | 0.1221 mL | 0.6106 mL | 1.2213 mL | 3.0532 mL | |
50 mM | 0.0489 mL | 0.2443 mL | 0.4885 mL | 1.2213 mL | |
100 mM | 0.0244 mL | 0.1221 mL | 0.2443 mL | 0.6106 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PF-04418948 1078166-57-0 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Inhibitor CHO PF 04418948 PF04418948 orally activity inhibit inhibitor