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Nedaplatin

Nedaplatin

产品编号 T2410   CAS 95734-82-0
别名: 奈达铂, NSC 375101D

Nedaplatin (NSC-375101D) 是顺铂的衍生物,是肿瘤集落形成单位的 DNA 损伤剂,IC50为94 μM。

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Nedaplatin Chemical Structure
Nedaplatin, CAS 95734-82-0
规格 价格/CNY 货期 数量
1 mg ¥ 187 现货
5 mg ¥ 417 现货
10 mg ¥ 672 现货
25 mg ¥ 1,330 现货
50 mg ¥ 2,090 现货
100 mg ¥ 3,130 现货
500 mg ¥ 6,990 现货
产品目录号及名称: Nedaplatin (T2410)
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纯度: 100%
纯度: 98.69%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucleophilic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death.
靶点活性 DNA damage:94 μM
体外活性 与这三种药物单独使用相比,在Nedaplatin或顺铂(FN或FC治疗)之前先连续使用5-FU给药对对肿瘤生长的抑制及存活时间的延长上具有协同加强作用.
体内活性 Nedaplatin (Aqupla)是顺铂衍生物,能抑制肿瘤克隆集落形成(IC50:28.5 μg/mL)。0.005-0.5 μg/mL的Nedaplatin对SBC-3细胞增殖的抑制效果为2%-98%(IC50:0.053 μg/mL)。
细胞实验 The inhibition of cell (including human SCLC cell line SBC-3 and human NSCLC cell line PC-14) proliferation after drug treatments as the antitumor activity using a regrowth assay is messured. Briefly, cells are exposed to drugs alone or in combination for 6 days at 37°C in an atmosphere of 100% humidity with 5% CO2; the cells are then pipetted six to eight times until almost all cells appeared as single cells and counted with a counter. For each drug, concentration-effect curves are drawn as plots of the fraction of surviving cells (unaffected cell fraction, fu) versus drug concentration. The cell proliferation ratio of the treated:control cultures (T:C%) is calculated as follows: [(the number of treated cells on day 6)/(the number of treated cells on day 0)]/[(the number of control cells on day 6)/(the number of control cells on day 0)] × 100%. The IC50 is defined as the drug concentration required for a 50% reduction in the number of cells. Four or five independent experiments are carried out for each. To check the effect of the drug treatment schedule on the effect of the combination, the cells are treated either by simultaneous exposure to the two drugs or by sequential exposure to Nedaplatin followed by irinotecan (Nedaplatin→irinotecan) and vice versa (irinotecan→Nedaplatin) for 3 hours. For the sequential exposure treatment, cells are exposed to the first drug for 3 hours, ished in fresh medium once, and then immediately exposed to the second drug for 3 hours. The treated cells are cultured in drug-free medium until evaluation.(Only for Reference)
别名 奈达铂, NSC 375101D
分子量 303.17
分子式 C2H8N2O3Pt
CAS No. 95734-82-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: Insoluble

H2O: 10 mM

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2985 mL 16.4924 mL 32.9848 mL 82.462 mL
5 mM 0.6597 mL 3.2985 mL 6.597 mL 16.4924 mL
10 mM 0.3298 mL 1.6492 mL 3.2985 mL 8.2462 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Alberts DS, et al. Cancer Chemother Pharmacol, 1997, 39(6), 493-497. 2. Wheate NJ et al. Dalton Trans, 2010, 39(35), 8113-8127. 3. Kanzawa F, et al. Clin Cancer Res, 2001, 7(1), 202-209. 4. Uchida N, et al.Eur J Cancer, 1998, 34(11), 1796-1801. 5. Matsumoto M, et al. Jpn J Cancer Res, 2001, 92(1), 51-58.
UNC9512 RG7800 tetrahydrochloride Amuvatinib Gallium maltolate Epieriocalyxin A RG7800 Licorisoflavan A 1,4-Dideoxy-1,4-epithio-D-ribitol

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 抗癌临床化合物库 抗癌药物库 抗癌上市药物库 已知活性化合物库 抗肺癌化合物库 经典已知活性库 细胞周期化合物库 上市药物库 毒性化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Nedaplatin 95734-82-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis 奈达铂 Inhibitor NSC 375101D inhibit inhibitor

 

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