Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVP-ADW742 (ADW) 是一种具有口服活性,选择性的IGF-1R 酪氨酸激酶抑制剂,IC50为 0.17 μM。它抑制胰岛素受体,IC50为 2.8 μM,在肿瘤细胞中诱导多效性抗增殖/促凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 393 | 现货 | ||
2 mg | ¥ 637 | 现货 | ||
5 mg | ¥ 943 | 现货 | ||
10 mg | ¥ 1,660 | 现货 | ||
25 mg | ¥ 3,250 | 现货 | ||
50 mg | ¥ 4,760 | 现货 | ||
100 mg | ¥ 6,780 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 943 | 现货 |
产品描述 | NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
靶点活性 | IGF-1R:0.17 μM |
体外活性 | CRT0044876 potently inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase activities of APE1, and exhibits the selectivity for the inhibition of exonuclease III family. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds with an accumulation of unrepaired AP sites. [1] CRT0044876, by inhibition of the BER pathway increases oxidative DNA damage temporally related to increased intracellular reactive oxygen species in an acidic tumor microenvironment, and thus results in cell cycle arrests and increased DNA double strand breaks, leading to cell death. [2] |
别名 | ADW742, ADW, GSK 552602A |
分子量 | 453.58 |
分子式 | C28H31N5O |
CAS No. | 475488-23-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 10 mg/mL (22.04 mM), Heating is recommended.
Ethanol: 3 mg/mL (6.61 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.2047 mL | 11.0234 mL | 22.0468 mL | 55.1171 mL |
5 mM | 0.4409 mL | 2.2047 mL | 4.4094 mL | 11.0234 mL | |
DMSO | 10 mM | 0.2205 mL | 1.1023 mL | 2.2047 mL | 5.5117 mL |
20 mM | 0.1102 mL | 0.5512 mL | 1.1023 mL | 2.7559 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NVP-ADW742 475488-23-4 Apoptosis Tyrosine Kinase/Adaptors IGF-1R inhibit Inhibitor hematologic multiple NVP-ADW-742 NVP ADW742 NVPADW742 ADW742 ADW 742 antiproliferative tumor Insulin Receptor InsR proapoptotic myeloma ADW-742 orally malignancies NVP-ADW 742 solid pleiotropic ADW GSK 552602A inhibitor