Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,具有抗原生动物和抗菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 284 | 现货 | ||
5 g | ¥ 368 | 现货 | ||
10 g | ¥ 662 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 395 | 现货 |
产品描述 | Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. |
体外活性 | Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. [1] Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole?has played an important role in anaerobic-related infections.? ?Metronidazole?has notable effectiveness in treating anaerobic brain abscesses. [2] Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. [3] Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. [4] |
别名 | Flagyl, Metronidazol, 甲硝唑, Anagiardil |
分子量 | 171.15 |
分子式 | C6H9N3O3 |
CAS No. | 443-48-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 32 mg/mL (187 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 5.8428 mL | 29.2141 mL | 58.4283 mL | 146.0707 mL |
5 mM | 1.1686 mL | 5.8428 mL | 11.6857 mL | 29.2141 mL | |
10 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
20 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
50 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
100 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Metronidazole 443-48-1 Apoptosis Metabolism Microbiology/Virology NADPH Hydrogenase Antibacterial Antibiotic Parasite Antifection Entamoeba histolytica iNOS Giardia lamblia anaerobic protozoa anaerobic infection adiponectin Flagyl inhibit eNOS Metronidazol 甲硝唑 Bacterial Bcl2 Cry2 Balantidium coli. Ror-β Inhibitor Trichomonas vaginalis Bax E4BP4. PP ARγ Anagiardil caspase-3 inhibitor