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Metronidazole

Metronidazole

产品编号 T1079   CAS 443-48-1
别名: Flagyl, Metronidazol, 甲硝唑, Anagiardil

Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,具有抗原生动物和抗菌活性。

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Metronidazole Chemical Structure
Metronidazole, CAS 443-48-1
规格 价格/CNY 货期 数量
500 mg ¥ 284 现货
5 g ¥ 368 现货
10 g ¥ 662 现货
1 mL * 10 mM (in DMSO) ¥ 395 现货
其他形式的 Metronidazole:
产品目录号及名称: Metronidazole (T1079)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
体外活性 Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. [1] Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole?has played an important role in anaerobic-related infections.? ?Metronidazole?has notable effectiveness in treating anaerobic brain abscesses. [2] Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. [3] Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. [4]
别名 Flagyl, Metronidazol, 甲硝唑, Anagiardil
分子量 171.15
分子式 C6H9N3O3
CAS No. 443-48-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 32 mg/mL (187 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8428 mL 29.2141 mL 58.4283 mL 146.0707 mL
5 mM 1.1686 mL 5.8428 mL 11.6857 mL 29.2141 mL
10 mM 0.5843 mL 2.9214 mL 5.8428 mL 14.6071 mL
20 mM 0.2921 mL 1.4607 mL 2.9214 mL 7.3035 mL
50 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
100 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Samuelson J, et al. Antimicrob Agents Chemother, 1999, 43(7), 1533-1541. 2. Dechant KL, et al. Drugs, 1991, 42(3), 428-467. 3. Sisson G, et al. J Bacteriol, 2000, 182(18), 5091-5096. 4. Nasirudeen AM, et al. Microbiology, 2004, 150(Pt 1), 33-43.

文献引用

1. Shan T, Huang Y, Zhao Z, et al. Ketogenic diet restrains herpes simplex encephalitis via gut microbes. Microbes and Infection. 2022: 105061. 2. Li F, Wang Y, Song X, et al. The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia. Gut Microbes. 2022, 14(1): 2096989 3. Lai S, Kumari A, Liu J, et al. Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase-induced cell ablation system in zebrafish larvae. Journal of Genetics and Genomics. 2021 4. Zhang Z, Ye J, Liu X, et al.Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis.Chinese Medicine.2023, 18(1): 1-15.

相关化合物库

该产品包含在如下化合物库中:
抗癌临床化合物库 抗癌药物库 抗寄生虫天然产物库 微生物天然产物库 抗癌上市药物库 抗寄生虫库 抗纤维化化合物库 FDA上市及药典收录分子库 DNA 损伤和修复分子库 天然产物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Metronidazole 443-48-1 Apoptosis Metabolism Microbiology/Virology NADPH Hydrogenase Antibacterial Antibiotic Parasite Antifection Entamoeba histolytica iNOS Giardia lamblia anaerobic protozoa anaerobic infection adiponectin Flagyl inhibit eNOS Metronidazol 甲硝唑 Bacterial Bcl2 Cry2 Balantidium coli. Ror-β Inhibitor Trichomonas vaginalis Bax E4BP4. PP ARγ Anagiardil caspase-3 inhibitor

 

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