首页 工具
登录
购物车
Losartan

Losartan

产品编号 T0215L   CAS 114798-26-4
别名: DuP-753, 氯沙坦, 洛沙坦

Losartan (DuP-753) 是一种血管紧张素II 受体拮抗剂,能够与血管紧张素II 竞争性结合AT1受体(IC50:20 nM)。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
Losartan Chemical Structure
Losartan, CAS 114798-26-4
规格 价格/CNY 货期 数量
500 mg ¥ 333 现货
1 g ¥ 418 现货
5 g ¥ 970 现货
1 mL * 10 mM (in DMSO) ¥ 418 现货
其他形式的 Losartan:
产品目录号及名称: Losartan (T0215L)
点击图片重新获取验证码
选择批次  
纯度: 100%
纯度: 99.79%
纯度: 99.53%
纯度: 99.48%
纯度: 99.37%
纯度: 98.80%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Losartan (DuP-753) is an angiotensin II receptor antagonist.
靶点活性 AT1 receptor:20 nM
体外活性 Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM[1]. Losartan (40?μM) affects ISC but prevents the effect of ANGII on ISC[2]. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone[3].
体内活性 Losartan (0.6 g/L, p.o.) -treated Fbn1C1039 g/+ mice show a reduction in distal airspace caliber relative to placebo-treated Fbn1C1039 g/+ animals. The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects. Analysis of pSmad2 nuclear staining reveals that losartan antagonizes TGF-β signaling in the aortic wall of Fbn1C1039 g/+ mice. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics[4]. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged[5].
细胞实验 An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.
别名 DuP-753, 氯沙坦, 洛沙坦
分子量 422.91
分子式 C22H23ClN6O
CAS No. 114798-26-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 198.6 mM

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3646 mL 11.8228 mL 23.6457 mL 59.1142 mL
5 mM 0.4729 mL 2.3646 mL 4.7291 mL 11.8228 mL
10 mM 0.2365 mL 1.1823 mL 2.3646 mL 5.9114 mL
20 mM 0.1182 mL 0.5911 mL 1.1823 mL 2.9557 mL
50 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
100 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5911 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
=
X
X
X
=
X
=
/
g/mol

输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12. 2. Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014. 3. Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31. 4. Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21. 5. Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40. 6. Zhang L, Zhang B, Yu Y, et al. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload[J]. International Heart Journal. 2021: 20-384 7. Zhang Y, Song Z, Huang S, et al. Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation[J]. Journal of Leukocyte Biology. 2020, 108(6): 1735-1746.

文献引用

1. Zhang Y, Song Z, Huang S, et al. Aloe emodin relieves Ang II‐induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation. Journal of Leukocyte Biology. 2020, 108(6): 1735-1746 2. Zhang L, Zhang B, Yu Y, et al. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. International Heart Journal. 2021: 20-384
Camellianin A Pivalopril Valsartan Moveltipril Imidapril hydrochloride Peimisine Omapatrilat A 779

相关化合物库

该产品包含在如下化合物库中:
抗癌上市药物库 抗癌药物库 抗癌临床化合物库 抗癌化合物库 GPCR靶点分子库 NO PAINS 化合物库 人代谢物化合物库 FDA 上市药物库 已知活性化合物库 肝脏毒性化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Losartan 114798-26-4 Endocrinology/Hormones RAAS DuP 753 Angiotensin Receptor DuP753 DuP-753 氯沙坦 inhibit Inhibitor 洛沙坦 inhibitor

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼