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Levofloxacin

Levofloxacin

产品编号 T6567   CAS 100986-85-4
别名: Levaquin, Cravit, Tavanic, Fluoroquinolone, 左氧氟沙星, (-)-Ofloxacin

Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素,有抑制细菌DNA 旋转酶的超螺旋活性的作用,能阻止DNA 复制。

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Levofloxacin Chemical Structure
Levofloxacin, CAS 100986-85-4
规格 价格/CNY 货期 数量
50 mg ¥ 298 现货
100 mg ¥ 418 现货
500 mg ¥ 553 现货
5 g ¥ 798 现货
1 mL * 10 mM (in DMSO) ¥ 460 现货
产品目录号及名称: Levofloxacin (T6567)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
体外活性 Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate?activity?against anaerobes.[1] Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more?active?than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.?Levofloxacin?inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. [2] Levofloxacin?exhibits twofold greater?inhibitory?and?bactericidal?activities?than ofloxacin?against?either extracellular or intracellular tubercle bacilli.?[3] Levofloxacin?has the least?inhibitory?effect on osteoblastic cell growth, with a 50%?inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis.[4] Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. [5]
体内活性 Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin. [2]
别名 Levaquin, Cravit, Tavanic, Fluoroquinolone, 左氧氟沙星, (-)-Ofloxacin
分子量 361.37
分子式 C18H20FN3O4
CAS No. 100986-85-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 12.5 mg/mL (34.59 mM)

Ethanol: 2 mg/mL(5.5 mM)

H2O: 9 mg/mL (24.9 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol / H2O 1 mM 2.7672 mL 13.8362 mL 27.6725 mL 69.1812 mL
5 mM 0.5534 mL 2.7672 mL 5.5345 mL 13.8362 mL
DMSO / H2O 10 mM 0.2767 mL 1.3836 mL 2.7672 mL 6.9181 mL
20 mM 0.1384 mL 0.6918 mL 1.3836 mL 3.4591 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Davis R, et al. Drugs,1994, 47(4), 677-700. 2. Fu KP, et al. Antimicrob Agents Chemother,1992, 36(4), 860-866. 3. Mor N, et al. Antimicrob Agents Chemother,1994, 38(5), 1161-1164. 4. Holtom PD, et al. J Orthop Res,2000, 18(5), 721-727. 5. Kato M, et al. Antimicrob Agents Chemother,1995, 39(9), 1979-1983. 6. Shen X, Zhang W, Peng C, et al. In vitro anti‐bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection[J]. Chinese medicine. 2021, 16(1): 1-19.

文献引用

1. Shen X, Zhang W, Peng C, et al. In vitro anti‐bacterial activity and network pharmacology analysis of Sanguisorba officinalis L. against Helicobacter pylori infection. Chinese medicine. 2021, 16(1): 1-19. 2. Yan J, Peng C, Chen P, et al. In-vitro anti-Helicobacter pylori activity and preliminary mechanism of action of Canarium album raeusch. Fruit extracts. Journal of Ethnopharmacology. 2021: 114578. 3. Kong Y, Geng Z, Jiang G, et al.Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China.Heliyon.2023
Camptothecin Lurtotecan Nalidixic acid Irinotecan hydrochloride trihydrate Isodiospyrin Lucidin primeveroside Cardioxane Pyrazoloacridine

相关化合物库

该产品包含在如下化合物库中:
抗癌上市药物库 抗癌药物库 抗癌临床化合物库 天然产物库 抑制剂库 上市药物库 抗感染天然产物库 肝脏毒性化合物库 抗感染化合物库 人代谢物化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Levofloxacin 100986-85-4 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Orthopoxvirus BK Viremia Levaquin inhibit Inhibitor Cravit DNA gyrase Tavanic airway inflammation Fluoroquinolone DNA/RNA Synthesis Bacterial Ofloxacin 左氧氟沙星 (-)-Ofloxacin chronic periodontitis inhibitor

 

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