Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 641 | 现货 | ||
5 mg | ¥ 1,580 | 现货 | ||
10 mg | ¥ 2,390 | 现货 | ||
25 mg | ¥ 3,960 | 现货 | ||
50 mg | ¥ 5,760 | 现货 | ||
100 mg | ¥ 7,860 | 现货 | ||
500 mg | ¥ 15,800 | 现货 |
产品描述 | IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
靶点活性 | IRAK4:7 nM. |
体外活性 | The in vitro metabolic stability profiles of IRAK4-IN-1 is measured, with EC50 of 2300 nM for the rat whole blood (RWB) |
体内活性 | Oral pharmacokinetic studies of IRAK4-IN-1 show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h. |
动物实验 | In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured. |
分子量 | 337.42 |
分子式 | C19H23N5O |
CAS No. | 1820787-94-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.29 mg/mL (42.35 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9637 mL | 14.8183 mL | 29.6367 mL | 74.0916 mL |
5 mM | 0.5927 mL | 2.9637 mL | 5.9273 mL | 14.8183 mL | |
10 mM | 0.2964 mL | 1.4818 mL | 2.9637 mL | 7.4092 mL | |
20 mM | 0.1482 mL | 0.7409 mL | 1.4818 mL | 3.7046 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IRAK4-IN-1 1820787-94-7 Immunology/Inflammation NF-Κb IRAK inhibit IRAK4 IN 1 Inhibitor IL-1R associated kinase Interleukin-1 receptor associated kinase IRAK4IN1 IRAK-4-IN-1 inhibitor