Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hexestrol (Hexanoestrol) 是非甾体合成雌激素,对雌激素受体ERα和ERβ的Ki=均为 0.06 nM。它可增加牛的体重,也可用于雌激素缺乏引起的疾病的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 329 | 现货 | ||
200 mg | ¥ 473 | 现货 | ||
500 mg | ¥ 782 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 185 | 现货 |
产品描述 | Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
靶点活性 | ERβ:0.175 nM(EC50), ERα:0.07 nM(EC50) |
体外活性 | Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6] |
体内活性 | Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7] |
别名 | Bibenzyl, 4,4'-(1,2-二乙基亚乙基)二苯酚, Hexanoestrol, meso-Hexestrol, Hexestrofen |
分子量 | 270.37 |
分子式 | C18H22O2 |
CAS No. | 84-16-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 39 mg/mL (144.2 mM)
Ethanol: 39 mg/mL (144.2 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 3.6986 mL | 18.4932 mL | 36.9864 mL | 92.4659 mL |
5 mM | 0.7397 mL | 3.6986 mL | 7.3973 mL | 18.4932 mL | |
10 mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 9.2466 mL | |
20 mM | 0.1849 mL | 0.9247 mL | 1.8493 mL | 4.6233 mL | |
50 mM | 0.074 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL | |
100 mM | 0.037 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hexestrol 84-16-2 Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor Bibenzyl estrogen 4,4'-(1,2-二乙基亚乙基)二苯酚 Hexanoestrol meso-Hexestrol Hexestrofen inhibit nonsteroidal Inhibitor synthetic inhibitor