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Ganciclovir

Ganciclovir

产品编号 T0688   CAS 82410-32-0
别名: BW 759, 更昔洛韦, RS-21592, 2'-Nor-2'-deoxyguanosine

Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物,对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。

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Ganciclovir Chemical Structure
Ganciclovir, CAS 82410-32-0
规格 价格/CNY 货期 数量
50 mg ¥ 344 现货
100 mg ¥ 485 现货
1 mL * 10 mM (in DMSO) ¥ 534 现货
其他形式的 Ganciclovir:
产品目录号及名称: Ganciclovir (T0688)
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选择批次  
纯度: 99.55%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
靶点活性 herpesvirus type-1 (FHV-1):5.2 μM
体内活性 In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[7].
激酶实验 For assessment of Akt protein kinase activity in vitro, substrate (2 μg histone H2B or 25 μg eNOS peptide) is incubated with Akt immunoprecipitated from cell lysate using goat polyclonal anti-Akt1 antibody. Kinase reactions are initiated following the addition of reaction components to a final concentration of ATP (50 μM) containing 10 μCi of 32P-γATP, dithiotreitol (1 mM), HEPES buffer (20 mM, pH 7.4), MnCl2 (10 mM), MgCl2 (10 mM). After incubation for 30 min at 30°C, phosphorylated histone H2B is visualized after SDS-PAGE (15%) and autoradiography. To estimate the extent of 32P incorporation into eNOS peptides, each reaction mixture is measured by spotting onto phosphocellulose disc filter and the amount of phosphate incorporated is measured by Cerenkov counting. The wild-type peptide sequence is 1174-RIRTQSFSLQERHLRGAVPWA-1194, and the mutant eNOS peptide is identical except that serine 1179 is substituted by alanine.
别名 BW 759, 更昔洛韦, RS-21592, 2'-Nor-2'-deoxyguanosine
分子量 255.23
分子式 C9H13N5O4
CAS No. 82410-32-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (195.9 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.918 mL 19.5902 mL 39.1803 mL 97.9509 mL
5 mM 0.7836 mL 3.918 mL 7.8361 mL 19.5902 mL
10 mM 0.3918 mL 1.959 mL 3.918 mL 9.7951 mL
20 mM 0.1959 mL 0.9795 mL 1.959 mL 4.8975 mL
50 mM 0.0784 mL 0.3918 mL 0.7836 mL 1.959 mL
100 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9795 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Matthews T, et al. Rev Infect Dis, 1988, 10, S490-494. 2. Hamel W, et al. Cancer Res, 1996, 56(12), 2697-2702. 3. St Clair MH, et al. Antimicrob Agents Chemother, 1987, 31(6), 844-849. 4. Wei SJ, et al. Exp Cell Res, 1998, 241(1), 66-75. 5. Rubsam LZ, et al. Cancer Res, 1998, 58(17), 3873-3882. 6. BoujemLa I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5. 7. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease[J]. Cell Death & Differentiation. 2021: 1-19. 8. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response[J]. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 9. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells[J]. Molecular cell. 2017 Nov 2;68(3):615-625.e9.

文献引用

1. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells. Molecular cell. 2017 Nov 2;68(3):615-625.e9. 2. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 3. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease. Cell Death & Differentiation. 2021: 1-19.
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相关化合物库

该产品包含在如下化合物库中:
抗癌临床化合物库 抗癌上市药物库 抗癌药物库 抗衰老化合物库 抗病毒库 FDA 上市药物库 儿童药物库 抗感染化合物库 抗生素库 药物片段库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Ganciclovir 82410-32-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Nucleoside Antimetabolite/Analog Antibiotic Antifection HSV CMV Inhibitor DNA BW-759 Herpes simplex virus RS 21592 serotype viruse BW 759 更昔洛韦 herpes inhibit RS-21592 BW759 polymerase orally active replication group infection CNS penetration Cytomegalovirus 2'-Nor-2'-deoxyguanosine RS21592 inhibitor

 

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