Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fipronil (Fluocyanobenpyrazole) 是昆虫GABA 受体的选择性拮抗剂,可抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏。在分离的大鼠肝微粒体中,它诱导细胞色素 P450 (CYP) 亚型CYP1A1/2、CYP2B1/2和CYP3A1/2的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 258 | 现货 | ||
25 mg | ¥ 413 | 现货 | ||
50 mg | ¥ 663 | 现货 | ||
100 mg | ¥ 980 | 现货 | ||
200 mg | ¥ 1,460 | 现货 | ||
500 mg | ¥ 2,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels, resulting in central nervous system toxicity. This causes hyperexcitation of contaminated insects' nerves and muscles. Specificity of fipronil on insects may come from a better efficacy on GABA receptor, but also because GluCl channels do not exist in mammals. |
别名 | 氟虫腈, Fluocyanobenpyrazole, Termidor |
分子量 | 437.15 |
分子式 | C12H4Cl2F6N4OS |
CAS No. | 120068-37-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (102.94 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2875 mL | 11.4377 mL | 22.8754 mL | 57.1886 mL |
5 mM | 0.4575 mL | 2.2875 mL | 4.5751 mL | 11.4377 mL | |
10 mM | 0.2288 mL | 1.1438 mL | 2.2875 mL | 5.7189 mL | |
20 mM | 0.1144 mL | 0.5719 mL | 1.1438 mL | 2.8594 mL | |
50 mM | 0.0458 mL | 0.2288 mL | 0.4575 mL | 1.1438 mL | |
100 mM | 0.0229 mL | 0.1144 mL | 0.2288 mL | 0.5719 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fipronil 120068-37-3 Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience P450 GluCls GABA Receptor 氟虫腈 γ-Aminobutyric acid Receptor Inhibitor CYPs Fluocyanobenpyrazole Termidor Gamma-aminobutyric acid Receptor inhibit Cytochrome P450 inhibitor