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Curcumin

Curcumin

产品编号 T1516   CAS 458-37-7
别名: Diferuloylmethane, Natural Yellow 3, 姜黄素, Indian Saffron, Turmeric yellow

Curcumin (Natural Yellow 3) 属于酚类天然产物,是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM),具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。

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Curcumin Chemical Structure
Curcumin, CAS 458-37-7
规格 价格/CNY 货期 数量
100 mg ¥ 373 现货
500 mg ¥ 545 现货
1 mL * 10 mM (in DMSO) ¥ 415 现货
其他形式的 Curcumin:
产品目录号及名称: Curcumin (T1516)
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纯度: 98.98%
纯度: 97.51%
纯度: 95%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
植物来源
产品描述 Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
靶点活性 p300 HAT:25 μM
体外活性 方法:视网膜母细胞瘤细胞 SO-Rb50 和 Y79 用 Curcumin (10-50 μM) 处理 24 h,使用 CCK-8 方法检测细胞活力。
结果:Curcumin 剂量依赖显著降低了 SO-Rb50 和 Y79 细胞的活力,IC50 分别为 38.4 μM 和 34.8 μM。[1]
方法:小鼠结肠癌细胞 MC38 用 Curcumin (5-50 μM) 处理 48 h,使用 Flow Cytometry 方法检测细胞凋亡情况。
结果:Curcumin 剂量依赖性诱导 MC38 细胞凋亡。[2]
方法:人胰腺癌细胞 PANC1 用 Curcumin (10-80  μg/mL) 处理 24 h,使用 Immunofluorescence 方法检测自噬标志物 LC3。
结果:点状自噬体在40 μg/mL Curcumin 处理组细胞中的表达水平最高。[3]
体内活性 方法:为检测体内抗肿瘤活性,将 Curcumin (100-200 mg/kg) 灌胃给药给携带小鼠结肠癌肿瘤 MC38 的 C57BL/6J 小鼠,每三天一次,持续三周。
结果:Curcumin 治疗组小鼠的平均肿瘤体积和肿瘤重量显著降低,200 mg/kg 治疗组的肿瘤体积和瘤重也显著低于 100 mg/kg 治疗组。[2]
方法:为检测体内抗肿瘤活性,将 Curcumin (25-50 mg/kg) 腹腔注射给携带艾氏腹水瘤 EAT 的 BALB/c 小鼠,每天一次,持续十天。
结果:Curcumin 50 mg/kg 组周围组织内 EAT 细胞数量明显少于肿瘤对照组。[4]
细胞实验 1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference)
别名 Diferuloylmethane, Natural Yellow 3, 姜黄素, Indian Saffron, Turmeric yellow
分子量 368.3799
分子式 C21H20O6
CAS No. 458-37-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 60 mg/mL (162.88 mM)

Ethanol: 1.8 mg/mL (5 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.7146 mL 13.5729 mL 27.1459 mL 67.8647 mL
5 mM 0.5429 mL 2.7146 mL 5.4292 mL 13.5729 mL
DMSO 10 mM 0.2715 mL 1.3573 mL 2.7146 mL 6.7865 mL
20 mM 0.1357 mL 0.6786 mL 1.3573 mL 3.3932 mL
50 mM 0.0543 mL 0.2715 mL 0.5429 mL 1.3573 mL
100 mM 0.0271 mL 0.1357 mL 0.2715 mL 0.6786 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Li Y, et al. Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway. BMC Cancer. 2018 Dec 10;18(1):1230. 2. Li P, et al. Curcumin selectively induces colon cancer cell apoptosis and S cell cycle arrest by regulates Rb/E2F/p53 pathway. J Mol Struct. 2022 Sep;1263:133180. 3. Zhu Y, et al. Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells. Evid Based Complement Alternat Med. 2017;2017:5787218. 4. Yılmaz S, et al. Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created. Iran J Basic Med Sci. 2019 Apr;22(4):418-425. 5. Odot J, et al. Int J Cancer. 2004, 111(3):381-387. 6. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 7. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1. 8. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin[J]. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15. 9. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 10. Tian D, Cao L, Li Q, et al. Benzannulated 5, 5-spiroketal sesquiterpenes from the roots of Angelica Pubescens[J]. Bioorganic Chemistry. 2021, 107: 104604.

文献引用

1. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway .Resveratrol inhibits proliferation,migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 2. Gou X, Tian D, Wei J, et al. New Drimane Sesquiterpenes and Polyketides from Marine-Derived Fungus Penicillium sp. TW58-16 and Their Anti-Inflammatory and α-Glucosidase Inhibitory Effects. Marine Drugs. 2021, 19(8): 416. 3. Tian D, Cao L, Li Q, et al. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens. Bioorganic Chemistry. 2021, 107: 104604 4. Liu Y P, Xie Z, Guan R Q, et al. Syzysamalactone, an Unusual 11-Carbon δ‑Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple). Journal of Natural Products. 2022 5. Sun L, Qian S, Ma Y, et al. Iron Overload Adversely Effects Bone Marrow Haematogenesis via SIRT-SOD2-MROS in a Process Ameliorated by Curcumin. Cellular & Molecular Biology Letters. 2021, 26(1): 1-15 6. Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1. 7. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 8. Wang W, Zeng Z, Zhang J, et al.A Systematic Study of Traditional Chinese Medicine for the Treatment of Lung Adenocarcinoma Using a Reverse Network of Key Targets Based on Bioinformatics and Molecular Docking: Curcumin and Trans-Resveratrol as Potential Drug Candidates for Lung Adenocarcinoma.Natural Product Communications.2023, 18(5): 1934578X231169370. 9. Bu H, Wang B, Wu Y, et al.Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage.Environmental Science and Pollution Research.2023: 1-17.
(E)-[6]-Dehydroparadol Nrf2 activator-3 NSC23925 AEM1 Ezetimibe Pelargonidin chloride Notoginsenoside R2 Nrf2-IN-1

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 抗癌药物库 抗癌活性化合物库 抗寄生虫天然产物库 抗癌临床化合物库 已知活性化合物库 高通量筛选天然产物库 抗阿尔茨海默症化合物库 人代谢物化合物库 肠道微生物代谢化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Curcumin 458-37-7 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Immunology/Inflammation Microbiology/Virology Mitophagy Epigenetic Reader Domain Ferroptosis Influenza Virus Nrf2 Histone Acetyltransferase HDAC Natural Yellow3 Diferuloylmethane HATs Natural Yellow 3 HAT Keap1-Nrf2 inhibit 姜黄素 Mitochondrial Autophagy Natural Yellow-3 Indian Saffron Turmeric yellow Inhibitor inhibitor

 

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