Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ciclesonide (Alvesco) 是一种糖皮质激素,具有强效抗炎活性,可用于研究哮喘。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 129 | 现货 | ||
5 mg | ¥ 252 | 现货 | ||
10 mg | ¥ 411 | 现货 | ||
25 mg | ¥ 748 | 现货 | ||
50 mg | ¥ 1,190 | 现货 | ||
100 mg | ¥ 1,930 | 现货 | ||
500 mg | ¥ 4,780 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases. |
体外活性 | Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2]. |
细胞实验 | Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference) |
别名 | Zetonna, 环索奈德, RPR251526, Omnaris, Alvesco |
分子量 | 540.69 |
分子式 | C32H44O7 |
CAS No. | 126544-47-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 54.1 mg/mL (100 mM)
DMSO: 54.1 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 1.8495 mL | 9.2474 mL | 18.4949 mL | 46.2372 mL |
5 mM | 0.3699 mL | 1.8495 mL | 3.699 mL | 9.2474 mL | |
10 mM | 0.1849 mL | 0.9247 mL | 1.8495 mL | 4.6237 mL | |
20 mM | 0.0925 mL | 0.4624 mL | 0.9247 mL | 2.3119 mL | |
50 mM | 0.037 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL | |
100 mM | 0.0185 mL | 0.0925 mL | 0.1849 mL | 0.4624 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ciclesonide 126544-47-6 Endocrinology/Hormones Glucocorticoid Receptor Inhibitor Zetonna 环索奈德 RPR 251526 RPR251526 Omnaris RPR-251526 inhibit Alvesco inhibitor