Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carbimazole (Athyromazole) 是咪唑类甲状腺拮抗试剂,在体内快速转化为 MMI 而发挥作用,在体外可转化为甲咪唑,可用于 Graves 病的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 331 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 415 | 现货 |
产品描述 | Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease. |
体内活性 | Carbimazole被人体吸收后转化为甲巯咪唑,产生抗甲状腺作用,作用于抗甲亢(过度产生甲状腺激素)和甲状腺毒症(甲状腺炎症)。 |
激酶实验 | In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot. |
别名 | 卡比马唑, Athyromazole, 卡比吗唑, Carbimazol, Neomercazole |
分子量 | 186.23 |
分子式 | C7H10N2O2S |
CAS No. | 22232-54-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 12 mg/mL (64.4 mM)
DMSO: 36 mg/mL (193.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 5.3697 mL | 26.8485 mL | 53.697 mL | 134.2426 mL |
5 mM | 1.0739 mL | 5.3697 mL | 10.7394 mL | 26.8485 mL | |
10 mM | 0.537 mL | 2.6849 mL | 5.3697 mL | 13.4243 mL | |
20 mM | 0.2685 mL | 1.3424 mL | 2.6849 mL | 6.7121 mL | |
50 mM | 0.1074 mL | 0.537 mL | 1.0739 mL | 2.6849 mL | |
DMSO | 100 mM | 0.0537 mL | 0.2685 mL | 0.537 mL | 1.3424 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Carbimazole 22232-54-8 Endocrinology/Hormones Thyroid hormone receptor(THR) antithyroid agent MMI inhibit Graves' disease 卡比马唑 Inhibitor Athyromazole methimazole 卡比吗唑 Carbimazol Neomercazole inhibitor