Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C29 是 Toll 样受体 2 抑制剂,可阻断 hTLR2/1 和 hTLR2/6 信号,IC50值分别为 19.7 和 37.6 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 663 | 现货 | ||
5 mg | ¥ 2,160 | 现货 | ||
10 mg | ¥ 3,220 | 现货 | ||
25 mg | ¥ 4,920 | 现货 | ||
50 mg | ¥ 6,830 | 现货 | ||
100 mg | ¥ 9,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,060 | 现货 |
产品描述 | C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. |
体外活性 | C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1]. |
体内活性 | C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40[1]. |
分子量 | 285.29 |
分子式 | C16H15NO4 |
CAS No. | 363600-92-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 60 mg/mL (210.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5052 mL | 17.526 mL | 35.0521 mL | 87.6301 mL |
5 mM | 0.701 mL | 3.5052 mL | 7.0104 mL | 17.526 mL | |
10 mM | 0.3505 mL | 1.7526 mL | 3.5052 mL | 8.763 mL | |
20 mM | 0.1753 mL | 0.8763 mL | 1.7526 mL | 4.3815 mL | |
50 mM | 0.0701 mL | 0.3505 mL | 0.701 mL | 1.7526 mL | |
100 mM | 0.0351 mL | 0.1753 mL | 0.3505 mL | 0.8763 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
C29 363600-92-4 Immunology/Inflammation TLR TLR2 Inhibitor hTLR2/1 inhibit C-29 Toll-like C 29 Toll-like Receptor (TLR) hTLR2/6 inhibitor