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C29

C29

产品编号 T3502   CAS 363600-92-4

C29 是 Toll 样受体 2 抑制剂,可阻断 hTLR2/1 和 hTLR2/6 信号,IC50值分别为 19.7 和 37.6 μM。

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C29 Chemical Structure
C29, CAS 363600-92-4
规格 价格/CNY 货期 数量
1 mg ¥ 663 现货
5 mg ¥ 2,160 现货
10 mg ¥ 3,220 现货
25 mg ¥ 4,920 现货
50 mg ¥ 6,830 现货
100 mg ¥ 9,180 现货
1 mL * 10 mM (in DMSO) ¥ 1,060 现货
产品目录号及名称: C29 (T3502)
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纯度: 98%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
体外活性 C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1].
体内活性 C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40[1].
分子量 285.29
分子式 C16H15NO4
CAS No. 363600-92-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: Insoluble

DMSO: 60 mg/mL (210.3 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5052 mL 17.526 mL 35.0521 mL 87.6301 mL
5 mM 0.701 mL 3.5052 mL 7.0104 mL 17.526 mL
10 mM 0.3505 mL 1.7526 mL 3.5052 mL 8.763 mL
20 mM 0.1753 mL 0.8763 mL 1.7526 mL 4.3815 mL
50 mM 0.0701 mL 0.3505 mL 0.701 mL 1.7526 mL
100 mM 0.0351 mL 0.1753 mL 0.3505 mL 0.8763 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. 2. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica[J]. Food & function. 2018 Jul 17;9(7):3930-3943. 3. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism[J]. International Journal of Biological Macromolecules. 2019, 137: 8-19. 4. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14. 5. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells[J]. Carbohydrate Polymer. 2020, 251: 117088.

文献引用

1. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells. Carbohydrate Polymer. 2020, 251: 117088. 2. Nie K, Zhang C, Deng M, et al. A Series of Genes for Predicting Responses to Anti-Tumor Necrosis Factor α Therapy in Crohn’s Disease. Frontiers in Pharmacology. 2022: 1195 3. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease. Journal of Neuroinflammation. 2019, 16(1): 1-14 4. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism. International Journal of Biological Macromolecules. 2019, 137: 8-19. 5. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food & function. 2018 Jul 17;9(7):3930-3943. 6. Zhang R, Tang L, Wang Y, et al.A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy.Advanced Science.2023: 2300116.
ABR-238901 CU-CPT-9a Pam3CSK4 TFA (112208-00-1 free base) Hydroxychloroquine Toll-like receptor modulator CL097 Atractylenolide I Polyinosinic-polycytidylic acid sodium

相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 非甾体类抗炎化合物库 免疫/炎症分子化合物库 经典已知活性库 已知活性化合物库 细胞焦亡化合物库 抗感染化合物库 抑制剂库 抗阿尔茨海默症化合物库 临床前化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

C29 363600-92-4 Immunology/Inflammation TLR TLR2 Inhibitor hTLR2/1 inhibit C-29 Toll-like C 29 Toll-like Receptor (TLR) hTLR2/6 inhibitor

 

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