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Bicalutamide

Bicalutamide

产品编号 T0380   CAS 90357-06-5
别名: 比卡鲁胺, ICI-176334

Bicalutamide (ICI-176334) 是一种具有口服活性的非甾体雄激素受体拮抗剂,可研究前列腺癌。

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Bicalutamide Chemical Structure
Bicalutamide, CAS 90357-06-5
规格 价格/CNY 货期 数量
50 mg ¥ 415 现货
100 mg ¥ 634 现货
200 mg ¥ 918 现货
500 mg ¥ 1,728 现货
1 g ¥ 2,698 现货
其他形式的 Bicalutamide:
产品目录号及名称: Bicalutamide (T0380)
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纯度: 99.97%
纯度: 99.88%
纯度: 98%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
靶点活性 Androgen Receptor:0.16 μM
体内活性 Single bicalutamide reduces tumor growth by 79%, at defined submaximal doses. The ridaforolimus-bicalutamide combination exhibits improved and potent antitumor activity, almost completely abrogating tumor growth. The combination is also well tolerated, as evidenced by no significant changes in body weight over the course of treatment. Plasma PSA levels are again tightly linked to tumor growth in the combination-treated mice. [3]
激酶实验 Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99.
细胞实验 Exponentially growing C4-2 cells are plated into two 96-well plates and incubated overnight at 37 ?C. Twenty-four hours later one plate is aspirated and stored at -80 ?C and the other treated with 10-fold serial concentrations of ridaforolimus (1000 nM to 0.0001 nM) or vehicle (ethanol). Following 72 hours culture at 37 ?C, the plates are assessed simultaneously for cell growth using the Cy qUANT Cell Proliferation Assay kit. Bicalutamide and Ridaforolimus combination proliferation assays are performed similarly except cell growth is determined as the change in cell number between vehicle control and compound treated cells after 72 hours in culture.(Only for Reference)
别名 比卡鲁胺, ICI-176334
分子量 430.37
分子式 C18H14F4N2O4S
CAS No. 90357-06-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 43 mg/mL (100 mM)

Ethanol: 4.3 mg/mL (10 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.3236 mL 11.6179 mL 23.2358 mL 58.0896 mL
5 mM 0.4647 mL 2.3236 mL 4.6472 mL 11.6179 mL
10 mM 0.2324 mL 1.1618 mL 2.3236 mL 5.809 mL
DMSO 20 mM 0.1162 mL 0.5809 mL 1.1618 mL 2.9045 mL
50 mM 0.0465 mL 0.2324 mL 0.4647 mL 1.1618 mL
100 mM 0.0232 mL 0.1162 mL 0.2324 mL 0.5809 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Clegg NJ, et al. Cancer Res. 2012, 72(6), 1494-1503. 2. Colquhoun AJ, et al. Prostate Cancer Prostatic Dis. 2012. 3. Squillace RM, et al. Int J Oncol. 2012.
Adenosine Adezmapimod Vps34-IN-1 Forskolin Verteporfin FERULIC ACID METHYL ESTER CaMKII-IN-1 Diazoxide

相关化合物库

该产品包含在如下化合物库中:
抗癌临床化合物库 抗癌药物库 抗癌上市药物库 抗癌活性化合物库 FDA 上市药物库 人代谢物化合物库 抗癌化合物库 药物功能重定位化合物库 儿童药物库 核受体化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Bicalutamide 90357-06-5 Autophagy Endocrinology/Hormones Androgen Receptor 比卡鲁胺 cancer androgen castration-resistant ICI 176334 receptor prostate cancer Inhibitor prostate ICI-176334 inhibit ICI176334 anti-androgen non-steroidal inhibitor

 

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