Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bedaquiline (R207910) 是一种二芳基喹啉药物,能同时靶向 c-亚基和 ε-亚基,抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 196 | 现货 | ||
5 mg | ¥ 443 | 现货 | ||
10 mg | ¥ 643 | 现货 | ||
25 mg | ¥ 989 | 现货 | ||
50 mg | ¥ 1,370 | 现货 | ||
100 mg | ¥ 1,980 | 现货 | ||
500 mg | ¥ 4,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 556 | 现货 |
产品描述 | Bedaquiline (R207910)(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
体外活性 | Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3]. |
别名 | R207910, TMC207, 贝达喹啉 |
分子量 | 555.5 |
分子式 | C32H31BrN2O2 |
CAS No. | 843663-66-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.56 mg/mL (10 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8002 mL | 9.0009 mL | 18.0018 mL | 45.0045 mL |
5 mM | 0.36 mL | 1.8002 mL | 3.6004 mL | 9.0009 mL | |
10 mM | 0.18 mL | 0.9001 mL | 1.8002 mL | 4.5005 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bedaquiline 843663-66-1 Microbiology/Virology Antibacterial Antibiotic R207910 TMC 207 Bacterial TMC-207 R 207910 R-207910 TMC207 Inhibitor 贝达喹啉 inhibit inhibitor