Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG-208 是一种选择性的、口服有活性的c-Met/RON 双抑制剂,对c-Met 的IC50为 9 nM。他也是CYP3A4抑制剂(IC50:32 μM)。它具有抗癌作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 329 | 现货 | ||
2 mg | ¥ 478 | 现货 | ||
5 mg | ¥ 788 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,320 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,480 | 现货 |
产品描述 | AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. |
靶点活性 | c-Met:9 nM |
体外活性 | AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM. [1] Incubation of AMG-208 with rat and human liver microsomes in the presence of NADPH qualitatively yields C6-phenylarene oxidation products as the major metabolites. [1] Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation. [2] AMG-208 is identified to be a c-MET and RON dual selective inhibitor. [3] |
体内活性 | In male Sprague?Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour, while AMG-208 (2 mg/kg i.v.) shows a bioavailability with AUC0→∞ of 2517 ng·h/mL and F of 43%, respectively. [1] |
别名 | AMG 208 |
分子量 | 383.4 |
分子式 | C22H17N5O2 |
CAS No. | 1002304-34-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.8 mg/mL (20.34 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6082 mL | 13.0412 mL | 26.0824 mL | 65.2061 mL |
5 mM | 0.5216 mL | 2.6082 mL | 5.2165 mL | 13.0412 mL | |
10 mM | 0.2608 mL | 1.3041 mL | 2.6082 mL | 6.5206 mL | |
20 mM | 0.1304 mL | 0.6521 mL | 1.3041 mL | 3.2603 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AMG-208 1002304-34-8 Metabolism Tyrosine Kinase/Adaptors P450 c-Met/HGFR inhibit CYPs Cytochrome P450 Inhibitor AMG 208 AMG208 inhibitor