Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-804598 是一个 CNS 渗透,竞争性和选择性的 P2X7受体拮抗剂,作用于小鼠、大鼠和人的 P2X7 受体,IC50s 分别是 9、10 和 11 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 235 | 现货 | ||
2 mg | ¥ 333 | 现货 | ||
5 mg | ¥ 543 | 现货 | ||
10 mg | ¥ 796 | 现货 | ||
25 mg | ¥ 1,680 | 现货 | ||
50 mg | ¥ 2,680 | 现货 | ||
100 mg | ¥ 3,990 | 现货 | ||
500 mg | ¥ 8,750 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 585 | 现货 |
产品描述 | A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |
靶点活性 | P2X7R (human):11 nM, P2X7R (rat):10 nM, P2X7R (rat):9 nM |
体外活性 | A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
体内活性 | According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2] |
别名 | A 804598 |
分子量 | 315.37 |
分子式 | C19H17N5 |
CAS No. | 1125758-85-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.5 mg/mL(100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1709 mL | 15.8544 mL | 31.7088 mL | 79.272 mL |
5 mM | 0.6342 mL | 3.1709 mL | 6.3418 mL | 15.8544 mL | |
10 mM | 0.3171 mL | 1.5854 mL | 3.1709 mL | 7.9272 mL | |
20 mM | 0.1585 mL | 0.7927 mL | 1.5854 mL | 3.9636 mL | |
50 mM | 0.0634 mL | 0.3171 mL | 0.6342 mL | 1.5854 mL | |
100 mM | 0.0317 mL | 0.1585 mL | 0.3171 mL | 0.7927 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
A-804598 1125758-85-1 Membrane transporter/Ion channel Neuroscience P2X Receptor A804598 A 804598 P2XRs Inhibitor inhibit inhibitor