Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3,3'-Diindolylmethane (DIM) 是一种小分子雄激素受体拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 234 | 现货 | ||
100 mg | ¥ 375 | 现货 | ||
500 mg | ¥ 544 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 164 | 现货 |
产品描述 | 3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent. |
体外活性 | DIM is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. DIM can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1]. |
体内活性 | Preliminary studies show DIM is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of DIM has radioprotection and mitigation properties in vivo. DIM Activates ATM in Normal Tissues. DIM can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1]. |
细胞实验 | The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference) |
别名 | HB 236, 二吲哚甲烷, DIM, Arundine |
分子量 | 246.31 |
分子式 | C17H14N2 |
CAS No. | 1968-05-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 18 mg/mL (73.08 mM)
DMSO: 24.6 mg/mL(100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 4.0599 mL | 20.2996 mL | 40.5992 mL | 101.4981 mL |
5 mM | 0.812 mL | 4.0599 mL | 8.1198 mL | 20.2996 mL | |
10 mM | 0.406 mL | 2.03 mL | 4.0599 mL | 10.1498 mL | |
20 mM | 0.203 mL | 1.015 mL | 2.03 mL | 5.0749 mL | |
50 mM | 0.0812 mL | 0.406 mL | 0.812 mL | 2.03 mL | |
DMSO | 100 mM | 0.0406 mL | 0.203 mL | 0.406 mL | 1.015 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
3,3'-Diindolylmethane 1968-05-4 Autophagy Endocrinology/Hormones Androgen Receptor HB 236 Inhibitor 3,3' Diindolylmethane HB-236 二吲哚甲烷 DIM HB236 3,3'Diindolylmethane inhibit Arundine inhibitor